![]() ![]() ![]() Increased cardiovascular mortality has been observed in hypopituitary patients that are GH deficient. Both hypertension and left ventricular hypertrophy improve with treatment (6-12 months) and survival is significantly greater in patients achieving disease remission.If GH levels remain elevated, long-acting somatostatin analogues, GH receptor anatagonists or radiotherapy can be used. Transphenoidal surgery with the resection of pituitary adenoma is the procedure of choice.Moreover, atrial, ventricular ectopy, sick sinus syndrome, supraventricular and ventricular beats may occur (1). ECG abnormalities including left axis deviation, septal Q-waves, ST-T wave depression, abnormal QT dispersion and conduction defects occurr in 50% of patients. Secondary hypertension occurs in 20-40% of patients with acromegaly and it is an independent factor for mortality in these patients. ![]() Additionally, right and left ventricular hypertrophy, aortic and mitral valve disease, which persist despite disease cure, are common findings. Hypertension, insulin resistance, diabetes mellitus and hyperlipidemia frequently occur in these patients. Risk depends on age, disease severity and duration. Growth hormone (GH) hypersecretion leads to acromegaly, which is associated with increased mortality due to cardiovascular disease. ![]() You will note that Diabetes Mellitus is not discussed in this article. The main glands, which are involved with the heart, are presented below. ![]()
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